Abcam, ab181237, Anti-RST antibody [EPR12312(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RST antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12312(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RST protein also known as RSTP1 has a significant role in cellular mechanics. It is a protein with a molecular mass of approximately 56 kDa and shows expression in multiple tissue types especially in the liver and heart. Functionally RST acts in the regulation of ion transport across cellular membranes. Its structure allows it to interact with both lipids and proteins facilitating effective shuttling of specific ions most notably calcium ions that are essential for maintaining proper cellular function.
Biological function summary
The mechanism of RST significantly contributes to the homeostasis of cellular ion concentrations. It forms part of the larger calcium ion regulation complex interacting closely with proteins like calmodulin. This interaction enables RST to play a vital part in maintaining calcium levels which is important for cellular signaling and muscle contraction processes. As part of the complex RST assists in the rapid response required during fluctuations in cellular ionic balance.
Pathways
Calcium ion regulation stands central where RST exerts its influence. Notably it participates in the signal transduction pathway which involves calcium as a second messenger to facilitate cellular responses to external stimuli. Additionally RST is involved in metabolic pathways that hinge on calcium concentration regulation working alongside related proteins such as phospholipase C which also has a role in signal transduction processes. These pathways are integral to maintaining cellular function and response to changes in the environment.
RST holds relevance in conditions related to calcium imbalance including cardiac arrhythmias and type 2 diabetes. In cardiac arrhythmias the dysregulation of RST can impact calcium channels influencing heart rhythm stability. Interactions with other proteins such as troponin compound these effects by further altering calcium sensitivity in cardiac tissues. In type 2 diabetes alterations in calcium signaling associated with RST maladaptations contribute to the insulin secretion process. These examples highlight RST’s varied influence on disease processes linked to signficant global health challenges.