Abcam, ab181560, Anti-Pan Trk antibody [EPR17341]

Size: 100µL / 1mL
Anti-Pan Trk antibody [EPR17341] (ab181560) is a rabbit monoclonal antibody detecting Pan Trk in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 30 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17341,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-Pan Trk antibody [EPR17341] (ab181560) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P and WB.
Abcam's high quality manufacturing and validation processes ensure Anti-Pan Trk antibody [EPR17341] (ab181560) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Pan Trk antibody [EPR17341] (ab181560) specifically detects Pan Trk (UniProt ID: Q16620; Molecular weight: 89kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EPR17341 -
ab218577
Antibody clone EPR17341 is also available pre-conjugated to a variety of labels for your convenience - HRP, Biotin, Alexa Fluor
488, Alexa Fluor
647, Alexa Fluor
594, Alexa Fluor
568, Alexa Fluor
555, Alexa Fluor
ab209465
ab252166
ab308600
ab311129
ab311762
ab313042
ab313243
ab321255
Enhanced validation in multi normal and malignant Tissue Microarrays. TRK is a key target for investigating neurotrophic receptors and signal transduction. It plays a crucial role in cancer therapy research, particularly in understanding NTRK gene fusions and their implications. TRK is widely analysed in studies of TRK inhibitors and neuroblastoma. Mutations and alterations in TRK are linked to various cancers, making it a significant target for developing targeted cancer therapies.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan Trk also known as tropomyosin receptor kinase (Trk) includes three different receptors: TrkA TrkB and TrkC. These belong to the neurotrophic tyrosine receptor kinase (NTRK) family each with a mass of roughly 140 kDa. They are mainly expressed in neuronal tissues but can also appear in non-neuronal tissues. The pan Trk term refers to antibodies that detect all three receptors simultaneously. These receptors play an important role in the cellular response to neurotrophins which are essential for differentiation survival and plasticity of neurons.
Biological function summary
The Trk receptors bind with neurotrophins such as nerve growth factor (NGF) brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) to initiate signaling that supports neuronal survival and growth. These receptors function as part of a larger receptor-ligand complex. Upon neurotrophin binding the Trk receptors undergo dimerization and transphosphorylation triggering downstream signaling cascades. This activation modulates cellular processes including synaptic strength enhancement and neuronal network formation.
Pathways
The Trk receptors activate important cellular signaling pathways such as the PI3K/AKT and MAPK/ERK pathways. These pathways regulate cell survival proliferation and differentiation. The Trk receptors interact with proteins like Shc PLCγ and Grb2 which facilitate signal transduction to multiple downstream effectors. This integration into signaling networks allows cross-talk with other signaling molecules and pathways orchestrating complex biological functions.
Pan Trk expression links to conditions like neurodegenerative diseases and certain cancers. Overexpression or mutation of Trk receptors can lead to oncogenesis particularly in tumor types like gliomas and neuroblastomas. Moreover abnormal Trk signaling has associations with Alzheimer's disease where dysregulated nerve growth factor signaling contributes to neurodegeneration. Targeted therapies and pan Trk inhibitors offer potential treatment strategies for these diseases by modulating receptor activity and correcting signaling pathway imbalances.