Abcam, ab181836, Anti-MTERF antibody [EPR14202]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MTERF antibody. Suitable for IHC-P, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14202,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MTERF (Mitochondrial Transcription Termination Factor) protein also known by alternative names like MTERF1 or h-mTERF functions mechanically by binding to mitochondrial DNA and regulating the transcription and replication processes. This protein with a mass of around 41 kDa exists predominantly in the mitochondria an organelle important for energy production in cells. MTERF plays an important role in ensuring proper mitochondrial function by terminating the transcription of mitochondrial genes.
Biological function summary
MTERF facilitates the control of gene expression within the mitochondria influencing the synthesis of essential components for the electron transport chain. It participates as part of a complex that interacts with mitochondrial DNA controlling the expression of the heavy and light strand promoters. These functions are necessary for maintaining mitochondrial DNA's integrity and proper cellular respiration.
Pathways
Mitochondrial biogenesis and homeostasis represent significant roles for MTERF particularly within the context of oxidative phosphorylation and apoptosis pathways. In oxidative phosphorylation MTERF ensures efficient energy production by regulating gene transcription. The protein interacts with other mitochondrial elements such as TFAM (Transcription Factor A Mitochondrial) and POLRMT (Mitochondrial RNA Polymerase) coordinating the replication and transcription processes.
MTERF has been connected to conditions like Mitochondrial Encephalopathy and Parkinson’s Disease. Disruptions in its function can affect mitochondrial integrity leading to neurological symptoms. MTERF is linked with proteins like COX1 and ATPase6 where its dysregulation can alter their expression contributing to disease pathogenesis. Understanding its role gives insight into developing therapeutic approaches targeting mitochondrial-related disorders.