Abcam, ab182163, Anti-KLHL6 antibody [EPR13484]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal KLHL6 antibody. Suitable for IP, WB, ICC/IF and reacts with Human, Transfected cell line - Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13484,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLHL6 also known as Kelch-like protein 6 is a member of the Kelch-like family of proteins. It plays a mechanistic role in protein-protein interactions mainly by acting as a substrate recognition component of an E3 ubiquitin ligase complex. KLHL6 has a molecular mass of approximately 52 kDa. This protein is primarily expressed in B cells and it is most abundant in the germinal center B cells within the lymphoid tissues.
Biological function summary
KLHL6 contributes to the regulation of B cell maturation and differentiation. Research indicates that KLHL6 is part of a Cul3-based E3 ubiquitin ligase complex which involves protein degradation processes. By functioning in this complex KLHL6 interacts with other proteins to ensure proper B cell development and immune responses. This function is important for maintaining normal immune system activities.
Pathways
KLHL6 plays a significant role in the B cell receptor (BCR) signaling pathway. This pathway is essential for B cell activation and differentiation. KLHL6 is associated with other pathway-related proteins such as BCR components and signaling molecules downstream in the pathway. Another key biological pathway involving KLHL6 is the ubiquitin-proteasome system which regulates protein turnover and influences various cellular processes by targeting proteins for degradation.
KLHL6 alteration has been linked to certain B cell malignancies such as chronic lymphocytic leukemia (CLL). Its expression levels or mutations might influence the progression of these diseases. The protein is also connected with other ubiquitin-proteasome pathway components such as the Cul3 E3 ligase complex which might affect these disorders' development. Understanding KLHL6's role in these contexts can provide insights into potential therapeutic targets.