Abcam, ab182398, Anti-PTF1A antibody [EPR19011]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PTF1A antibody. Suitable for IP, WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19011,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTF1A also known as pancreas specific transcription factor 1a or PTFL is a bHLH (basic Helix-Loop-Helix) transcription factor with a mass of approximately 35 kDa. This protein functions as a DNA-binding protein that regulates gene expression. It is mainly expressed in the pancreas especially within pancreatic progenitor cells and also in certain neural tissues. PTF1A is necessary for the transcriptional activity of genes involved in pancreatic development.
Biological function summary
The PTF1A protein plays a significant role in pancreas development and maintenance. It forms a complex as part of the pancreas transcription factor 1 (PTF1) complex which includes other proteins like RBPJL and the E-box binding protein. This complex binds to specific regulatory regions of DNA to modulate the expression of genes important for acinar cell differentiation and function in the pancreas.
Pathways
PTF1A operates within the Notch signaling pathway and the Wnt signaling pathway. In the Notch pathway PTF1A interacts with proteins such as Notch receptors and target HES genes to influence cell differentiation. Within the Wnt pathway PTF1A impacts genes involved with cell fate decisions during pancreatic development working with signaling proteins like beta-catenin to mediate its effects.
PTF1A mutations are associated with pancreatic agenesis and cerebellar atrophy. Pancreatic agenesis involves the underdevelopment or absence of the pancreas resulting in glucose homeostasis complications. PTF1A can interact with genes such as PDX1 in this context which is another transcription factor involved in pancreatic development. In cerebellar atrophy the disruptions in PTF1A expression can lead to problems with cerebellar development causing neurological symptoms due to its interaction with neural development pathways.