Abcam, ab182577, Anti-ACTR3B antibody [EPR14091]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACTR3B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14091,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACTR3B also known as Actin-related protein 3B is a component of the ARP2/3 complex which contains approximately 47 kDa. Mechanically ACTR3B plays a role in the regulation of actin polymerization which is essential for the formation of branched actin networks. ACTR3B expression occurs in various tissues with prominent levels in cells requiring dynamic cytoskeletal changes. It interacts closely with other proteins of the ARP2/3 complex to drive actin network formation.
Biological function summary
ACTR3B influences cellular processes related to the maintenance of cell shape and motility by being part of the ARP2/3 complex. This complex assists in the nucleation of new actin filaments contributing to the dynamic remodeling of the actin cytoskeleton. The activity of ACTR3B impacts cell migration cell division and intracellular transport by reorganizing actin structures. ACTR3B's role within the ARP2/3 complex underlines its involvement in cellular projects demanding changes to cell morphology and interaction with the environment.
Pathways
The involvement of ACTR3B in the regulation of actin polymerization positions it within the WASP/WAVE signaling pathways. These pathways orchestrate the actin cytoskeletal dynamics that direct important cellular movements such as lamellipodia formation. ACTR3B works alongside proteins like WASP (Wiskott-Aldrich Syndrome Protein) in its pathway activities supporting coordinated cellular responses to external and internal signals through cytoskeletal rearrangement.
ACTR3B's association with actin polymerization links it to cancers and immune system diseases including Wiskott-Aldrich syndrome. These diseases often involve defects in cell movement and signaling due to impaired actin dynamics. In the context of cancer altered expression or mutation of ACTR3B may support metastatic processes through disrupted cell adhesion and migration. Additionally ACTR3B's connection with WASP highlights its potential role in disorders where actin cytoskeletal defects significantly affect immune responses.