Abcam, ab183073, Anti-Prostaglandin E Receptor EP1/PTGER1 antibody

Size: 100µL
Rabbit Polyclonal Prostaglandin E Receptor EP1/PTGER1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PTGER1 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PTGER1 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P34995

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Prostaglandin E Receptor EP1 also known as PTGER1 is a protein encoded by the PTGER1 gene. It belongs to the G-protein-coupled receptor family and is recognized for its role in binding prostaglandin E2 (PGE2). PTGER1 is a transmembrane protein which traverses the cell membrane multiple times. This receptor has a molecular mass of approximately 42 kDa. It is expressed in various tissues including the kidney lung and stomach which suggests its role in different physiological processes.
Biological function summary
PTGER1 plays a significant role in modulating vascular smooth muscle function. It does not operate as a part of a larger protein complex but rather works independently to initiate cellular responses upon binding with PGE2. The activation of PTGER1 influences various physiological processes such as inflammation pain perception and smooth muscle contraction. It achieves this by enabling the intracellular signaling that contributes to these bodily responses.
Pathways
PTGER1 functions in essential signaling cascades particularly the prostaglandin signaling pathway. Also it interfaces with the G-protein coupled receptor signaling pathway which involves proteins such as Gq/11. PTGER1 activation can both amplify and regulate the downstream signaling events linking the receptor to processes involved in inflammation and pain response.
PTGER1's regulation of inflammation and smooth muscle contraction connects it to conditions such as hypertension and gastric ulcers. Altered expression or function of PTGER1 may contribute to these diseases by affecting blood pressure regulation and gastric mucosal integrity. In context of gastric ulcers PTGER1 engages with cyclooxygenase-2 (COX-2) a known mediator of inflammation and ulcerogenesis suggesting a potential area for therapeutic intervention by targeting this receptor.