Abcam, ab183269, Anti-SLAM / CD150 antibody [IPO-3] - BSA and Azide free

Size: 100µg
Mouse Monoclonal SLAM / CD150 antibody. Carrier free. Suitable for ELISA, Flow Cyt and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:IPO-3,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Epitope:The exact epitope recognised by this antibody has not been mapped.,
Specificity:This antibody is specific for SLAM.

Product details:
A novel glycoprotein of 70kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) / CDw150, that belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane-bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and that the expression levels of membrane-bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signaling through homophilic SLAM-SLAM binding during B-B and B-T cell interactions enhances the expansion and differentiation of activated B cells.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.6, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLAM also known as CD150 is a cell surface glycoprotein with a molecular weight of approximately 70 kDa. It is mainly expressed on immune cells such as T cells B cells dendritic cells and macrophages. SLAM/CD150 serves as a receptor that plays an important role in cellular communication by transmitting signals across the cell membrane. These signals influence various immune responses and cellular functions.
Biological function summary
SLAM/CD150 acts as a co-stimulatory molecule that augments the activation and proliferation of T and B cells. It participates in forming signaling complexes through interactions with SLAM-associated protein (SAP). As part of these complexes SLAM/CD150 regulates cytokine production and modulates immune cell interactions and responses. Furthermore SLAM/CD150 engagement impacts the stability and formation of immunological synapses.
Pathways
SLAM/CD150 plays a significant role in the immune signaling cascade. It is involved in the SLAM receptor signaling pathway and interacts closely with proteins like SAP and SH2D1A. These interactions enable signal transduction that modulates downstream effects in T and B cell activation within the immune system. SLAM/CD150's activity affects lymphocyte development and adaptive immune responses.
SLAM/CD150 is connected to autoimmune disorders and infectious diseases. Its altered signaling contributes to disorders such as X-linked lymphoproliferative disease where interactions with the SAP protein are disrupted. Additionally SLAM/CD150 serves as a receptor for certain viruses including measles virus implicating it in viral pathogenesis and immune evasion mechanisms. Understanding these associations helps elucidate potential therapeutic targets for managing these conditions.