Abcam, ab183512, Anti-Plakophilin 1 antibody [EPR14890]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Plakophilin 1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14890,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Plakophilin 1 also known as PKP1 is an important component of the cell's structural and signaling machinery. It is a member of the arm-repeat family of proteins and has a molecular mass of around 83 kDa. Plakophilin 1 is expressed in various epithelial tissues where it plays an important role in stabilizing cell junctions. It localizes mainly to desmosomes which are adhesive structures that connect cells together maintaining tissue integrity.
Biological function summary
This protein is a core part of desmosomal plaques which are thickened structures on the inner surface of cell membranes where desmosomes attach. Plakophilin 1 assists in linking the cadherin-catenin complex to intermediate filaments in the cytoskeleton promoting cell-cell adhesion. It is part of a larger protein complex that ensures mechanical strength and resilience across epithelial layers.
Pathways
Plakophilin 1 is involved in the assembly and organization of desmosomal junctions which are part of the broader adherens junction pathway. It interacts with several key proteins including desmoplakin and plakoglobin contributing to the stability and function of cell adhesions. These interactions are essential for maintaining the structural integrity and signaling capabilities of epithelial tissues.
Plakophilin 1 mutations have been linked to ectodermal dysplasia-skin fragility syndrome a condition characterized by compromised skin integrity and hair anomalies. This protein is also associated with certain types of cardiomyopathy due to its role in desmosomal structure and cell adhesion. Its interaction with desmoplakin is particularly relevant in these disorders where faulty cell junctions lead to tissue fragility and pathological conditions.