Abcam, ab183522, Anti-PRICKLE3 antibody

Size: 200µL
Goat Polyclonal PRICKLE3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRICKLE3 aa 500-550.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRICKLE3 aa 500-550. The exact immunogen used to generate this antibody is proprietary information.O43900

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab183522 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRICKLE3 also known by other names such as Prickle-like protein 3 and Testis expressed protein 44 (TEX44) is a protein characterized by its mechanistic roles related to cellular signaling. It is a part of the Prickle family which is known for planar cell polarity functions. PRICKLE3 weighs approximately 60 kDa. Expression of PRICKLE3 is noted in various tissues with higher expression in brain and testis where it likely participates in critical cellular activities.
Biological function summary
PRICKLE3 serves critical functions in cellular orientation and signaling pathways that are important for development and differentiation. It can form part of a protein complex implicated in intracellular signal transduction. This complex has been shown to interact with other proteins in the Prickle family to mediate planar cell polarity which is vital for various developmental processes both cellular and organismal.
Pathways
PRICKLE3 engages in the Wnt signaling pathway and the planar cell polarity (PCP) signaling pathway. These pathways are important for controlling cell movement and positioning. In the PCP pathway PRICKLE3 works alongside other proteins such as Dishevelled Van Gogh and Flamingo to regulate cell alignment and directional growth. Disruptions in these pathways can have significant impacts on biological processes leading to developmental anomalies.
PRICKLE3 has been linked to conditions such as epilepsy and cognitive impairments. Alterations in its function or expression can influence synaptic activity and neurodevelopmental processes. In particular the protein's interaction with Dishevelled in the PCP pathway highlights its potential role in disorders where these pathways are dysfunctional. Understanding these connections can provide insight into new therapeutic avenues for these neurological conditions.