Abcam, ab183529, Anti-Septin 11 antibody

Size: 100µg
Rabbit Polyclonal Septin 11 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN11 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEPTIN11 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9NVA2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab183529 was affinity purified using an epitope specific to Septin 11 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Septin 11 also known as SEPT11 functions as a GTPase involved in the formation of filamentous structures. This protein has a molecular mass of approximately 49 kDa. It is expressed in a wide range of tissues but most abundantly in the brain. Septin 11 belongs to the septin family which consists of cytoskeletal proteins important for cellular processes like cytokinesis and vesicle trafficking.
Biological function summary
The protein plays a role in cellular structure and integrity forming a complex with other septins to maintain cellular shape and facilitate mitotic processes. Septin 11 participates in organizing the actin cytoskeleton which affects cell division and movement. Its interaction with microtubules also suggests roles in intracellular transport and neural communication.
Pathways
Septin 11 is involved in actin and microtubule dynamics. It interacts with pathways that govern cellular cycle regulation and signal transduction. Related proteins like Septin 2 and Septin 9 play interactive roles in these pathways contributing to the complex orchestration of cellular organization and division. Their coordinated function ensures proper cell cycle progression and developmental processes.
Abnormalities in Septin 11 expression or function link to neurodegenerative diseases and cancer. Dysregulation can contribute to conditions such as Alzheimer's disease potentially through its interactions with tau proteins. Additionally altered Septin 11 expression associates with tumorigenesis as seen in some forms of leukemia where it interacts with proteins like BCR-ABL. Understanding Septin 11’s role in these diseases aids in the development of targeted therapeutic strategies.