Abcam, ab183655, Anti-NPAS1 antibody

Size: 100µL
Rabbit Polyclonal NPAS1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NPAS1 aa 100-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NPAS1 aa 100-400. The exact immunogen used to generate this antibody is proprietary information.Q99742

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NPAS1 also known as Neuronal PAS domain protein 1 functions as a transcription factor involved in various cellular processes. This protein has an approximate mass of 65 kDa. Researchers commonly observe NPAS1 expression in the brain particularly within the central nervous system. The protein contains a basic helix-loop-helix (bHLH) domain which facilitates its role in DNA binding and transcription regulation.
Biological function summary
NPAS1 exerts significant influence over neuronal development and function. The protein partners with ARNT (Aryl hydrocarbon receptor nuclear translocator) to form a heterodimeric complex a configuration necessary for initiating transcription of certain target genes. NPAS1 plays a critical role in moderating genes linked to brain development signaling and maintenance of neuronal activity. These activities ensure proper communication and functionality of neurons influencing overall central nervous system homeostasis.
Pathways
NPAS1 directly interacts with signaling networks that manage circadian rhythms and neurodevelopmental pathways. It influences the circadian clock machinery interacting with other proteins like CLOCK and BMAL1 to regulate the expression of genes controlling biological rhythms. Additionally in neurodevelopmental circuits NPAS1 modulates pathways linked to synaptic plasticity and neuronal differentiation impacting proteins such as RORα and FOXP2 which are important for implementing transcriptional responses essential for brain development.
NPAS1 has connections to schizophrenia and neurodegenerative disorders. Abnormal NPAS1 expression or function may contribute to the pathophysiology of schizophrenia influencing genes and pathways critical for neuronal stability and neurotransmitter regulation. Also NPAS1 demonstrates interactions with proteins such as DISC1 often implicated in schizophrenia and mental health conditions. In addition some evidence suggests potential involvement in neurodegenerative diseases where NPAS1's role in neuronal survival and stress response maintenance becomes disrupted affecting proteins like tau associated with Alzheimer’s disease.