Abcam, ab184099, Anti-Clusterin beta chain antibody [EPR17538-101]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Clusterin antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17538-101,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Clusterin beta chain also known as Apolipoprotein J is part of the clusterin protein complex that goes through heterodimerization to form a mature glycoprotein composed of alpha and beta chains. The estimated mass of the clusterin beta chain subunit is around 35-40 kDa. This protein is present in many tissues throughout the body with higher expression noted in the brain testes and kidneys as well as in blood plasma. It functions in molecular chaperoning and stabilizes numerous proteins and cells under stressful conditions.
Biological function summary
Clusterin beta chain engages in diverse functions related to cell apoptosis cell signaling and lipid transport. It is part of a secreted glycoprotein complex that includes an alpha chain. In the extracellular space it plays a significant role in inhibiting programmed cell death while also engaging in the regulation of immune responses. Its molecular chaperone capability safeguards cells from aggregation-prone stressors.
Pathways
Clusterin beta chain interacts with pathways associated with neuroprotection and immune regulation. It significantly participates in the apoptosis signaling pathway where it relates to other proteins such as Bax and Bcl-2 family members. Additionally its presence in the complement cascade relates it to complement component proteins such as C1q and C3 indicating its involvement in immune responses.
Clusterin beta chain relates strongly to neurodegenerative diseases and some cancers. In Alzheimer's disease its interaction with amyloid-beta highlights its potential impact in amyloid plaque formation and clearance. It associates with amyloid precursor proteins in the disease mechanism. Furthermore in various cancer progressions its altered expression links to tumor suppression and metastasis. Proteins like p53 and Hsp70 display interactions with clusterin beta chain within these contexts influencing tumor cell survival and spread.