Abcam, ab184186, Anti-AGPS antibody [EPR13120] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AGPS antibody. N-terminal. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13120,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AGPS also known as alkylglycerone phosphate synthase represents an important enzyme in lipid metabolism with a molecular mass of approximately 73 kDa. It catalyzes the formation of alkylglycerone phosphate from dihydroxyacetone phosphate and fatty alcohols a reaction that occurs in peroxisomes. AGPS is expressed in various tissues with high levels observed in the brain heart and reproductive organs. Its expression is important for proper plasmalogen synthesis an essential lipid component of cell membranes.
Biological function summary
AGPS functions as an important component in the synthesis of ether lipids specifically plasmalogens which play a role in membrane structure and signaling. Plasmalogens are phospholipids that are part of cellular membranes and influence membrane fluidity and dynamics. AGPS operates as a sole enzyme in the initial step of de novo plasmalogen biosynthesis engaging with other enzymes to complete this lipid complex. Its activity ensures the proper formation of plasmalogens which are particularly abundant in the heart and nervous tissues.
Pathways
AGPS plays a central role in the ether lipid biosynthesis pathway and interacts with proteins involved in lipid metabolism. Plasmalogen biosynthesis is a critical pathway where AGPS catalyzes the first step acting as a precursor in the synthesis of several ether lipids. Within the biosynthetic pathway AGPS works alongside enzymes such as fatty acyl-CoA reductase highlighting its collaboration with other proteins to regulate lipid homeostasis in cellular membranes.
Defects in AGPS can relate to conditions such as rhizomelic chondrodysplasia punctata (RCDP) and Zellweger spectrum disorders. RCDP presents severe skeletal malformations among other symptoms while Zellweger disorders involve multiple organ dysfunctions due to peroxisomal biogenesis issues. Mutations in AGPS often result in developmental delays and neurological impairment. Additionally AGPS dysfunction affects proteins like PEX7 which is important for targeting peroxisomal enzymes further exacerbating the disease phenotypes associated with these conditions.