Abcam, ab184550, Anti-NOLC1 antibody [EPR14896]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NOLC1 antibody. Suitable for WB, IHC-P, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14896,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NOLC1 which also goes by the alternative name nucleolar and coiled-body phosphoprotein 1 has an important role in cellular mechanics. This protein weighs around 76 kDa. NOLC1 localizes in the nucleolus which means it has a strong connection to ribosome biogenesis in the cell. You will often find NOLC1 expressed in various human tissues particularly those with high proliferative capacity.
Biological function summary
Nucleolus assembly and maintenance depend notably on pathways involving NOLC1. It acts as part of an essential multiprotein complex. NOLC1 interacts with other nucleolar proteins to maintain nucleolar structure and facilitate ribosomal RNA (rRNA) synthesis. Its activities support the structural and functional integrity needed for efficient ribosome production.
Pathways
Ribosome biogenesis forms the critical framework where NOLC1 operates. This protein interacts closely within the RNA polymerase I transcription machinery and rRNA processing pathways working alongside proteins like fibrillarin and UBF1. NOLC1's presence within these pathways helps in coordinating the transcriptional and structural elements necessary for ribosome assembly.
Aberrant NOLC1 function links to cancer and neurodegenerative diseases. Elevated NOLC1 levels sometimes correlate with increased tumor growth connecting it to malignant processes. Its interactions with proteins such as tumor protein p53 highlight its importance in regulating cell cycle and stress responses. Additionally disruptions in its nucleolar roles have potential associations with neurodegenerative disorders indicating its critical role beyond normal cellular functions.