Abcam, ab184691, Anti-KCNA5/KV1-5 antibody [2D10.D6]

Size: 50µL
Mouse Monoclonal KCNA5/KV1-5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KCNA5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2D10.D6,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KCNA5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P22460

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The KCNA5 protein also known as KV1.5 is a voltage-gated potassium channel. It has a molecular mass of approximately 70 kDa. KCNA5 facilitates potassium ion flow across cardiac and neuronal cell membranes. This protein predominantly expresses in the heart and the central nervous system. It plays a significant role in repolarizing cardiac action potentials contributing to cardiac rhythm regulation.
Biological function summary
KCNA5 functions as part of the KV1 family of potassium channels. It contributes to determining the duration of the action potential by mediating the delayed rectifier current. KCNA5 often forms tetrameric complexes which consist of four KCNA5 subunits or sometimes it forms heteromultimers with other potassium channels. This ability to form functional complexes allows it to modulate cellular excitability efficiently.
Pathways
KCNA5 interacts with various cellular processes essential for cardiac and neuronal function. It is involved in the cardiac action potential pathway where it influences the duration and frequency of heartbeats. Moreover KCNA5 participates in the regulation of neuronal excitability through the modulation of potassium ion conductivity. It interacts with proteins such as KCNA4 and KCNA2 which also contribute to similar physiological pathways to modulate excitability.
Abnormalities in KCNA5 expression or function link to cardiac arrhythmias such as atrial fibrillation due to its role in cardiac repolarization. Additionally studies suggest a relevance to neurodegenerative disorders although research in this area is ongoing. KCNA5's relation to atrial fibrillation associates it with proteins like KCNE1 which modulate similar ion channels involved in cardiac electrical activity.