Abcam, ab184778, Anti-C6orf134/TAT antibody

Size: 100µL
Rabbit Polyclonal C6orf134/TAT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATAT1 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ATAT1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q5SQI0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C6orf134 also known as TAT codes for a protein that functions in enzymatic activity catalyzing chemical reactions within cells. This protein has a molecular mass of approximately 59 kDa. It is found expressed in a variety of tissues but shows higher expression in liver tissue. Its enzymatic role involves processes that rely on its catalytic ability impacting cell metabolism and energy regulation.
Biological function summary
The enzyme affects metabolic pathways and amino acid metabolism. It plays a part in the conversion of specific substrates within these systems balancing energy flow and the availability of key metabolites. It can function as either an isolated enzyme or as part of larger enzymatic complexes depending on the cellular environment and metabolic demands.
Pathways
C6orf134 is deeply involved in the urea cycle and gluconeogenesis. These pathways play a critical role in managing nitrogen disposal and producing glucose when energy is needed. The enzyme operates alongside proteins such as carbamoyl phosphate synthetase 1 in the urea cycle and is related to phosphoenolpyruvate carboxykinase in gluconeogenesis affecting both nitrogen balance and glucose production.
Deficiencies or dysregulations of the enzyme relate to metabolic disorders such as tyrosinemia and hyperammonemia. These conditions connect C6orf134 to proteins like fumarylacetoacetate hydrolase and ornithine transcarbamylase as they are part of the metabolic networks disrupted in these disorders. Studying these connections helps understand how metabolic imbalances lead to disease symptoms.