Abcam, ab184952, Anti-NDUFA8 antibody [EPR15303]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NDUFA8 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15303,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFA8 also known as the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 is a protein with a mass of approximately 23 kDa. Mechanically it is an integral component of the mitochondrial respiratory chain specifically part of Complex I. This protein is expressed in multiple tissues with high levels in energy-demanding organs such as the heart brain and muscles. NDUFA8 plays a role in the catalytic activity of Complex I contributing to electron transfer and assisting in the creation of the proton gradient essential for ATP production.
Biological function summary
NDUFA8 participates in energy metabolism by facilitating the initial steps of the oxidative phosphorylation pathway. It is a subunit of Complex I also known as NADH:ubiquinone oxidoreductase one of the largest components in the mitochondrial inner membrane. This complex is important for the transfer of electrons from NADH to ubiquinone contributing to a process that generates ATP. NDUFA8 through its interaction within this complex helps regulate mitochondrial function and cellular energy balance.
Pathways
Energy metabolism involves the participation of NDUFA8 in the oxidative phosphorylation and mitochondrial electron transport chain pathways. These pathways are important for energy production in the form of ATP synthesis. NDUFA8 operates closely with other Complex I subunits and works in tandem with related complexes like Complexes II III and IV. Proteins such as NDUFA1 and NDUFB5 are important partners within these pathways ensuring the efficient execution of electron transport and ATP generation.
Defects in NDUFA8 have associations with mitochondrial disorders and neurodegenerative diseases. Mutations or dysfunctions in NDUFA8 can contribute to conditions such as Leigh syndrome and Complex I deficiency. These disorders involve impaired mitochondrial function leading to neurodegenerative symptoms and energy production deficits. Proteins connected to these diseases including other Complex I components like NDUFS4 exhibit interactions that highlight their critical roles in maintaining cellular energy homeostasis and neurological function.