Abcam, ab185333, Anti-TMEM119 antibody - C-terminal - Microglial marker

Size: 100µL
Anti-TMEM119 antibody - C-terminal (ab185333) is a rabbit polyclonal antibody detecting TMEM119 in IHC-P . Suitable for Human . - Over 40 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM119 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q4V9L6

Product details:
Product Specifications
Anti-TMEM119 antibody - C-terminal (ab185333) is a rabbit polyclonal antibody and is validated for use in IHC-P in human samples.
Anti-TMEM119 antibody - C-terminal (ab185333) specifically detects TMEM119 (UniProt ID: Q4V9L6; Molecular weight: 26kDa) and is sold in 100µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-TMEM119 antibody - C-terminal (ab185333) has high sensitivity and specificity.
Anti-TMEM119 antibody - C-terminal (ab185333) has been cited over 40 times in peer reviewed journals and is trusted by the scientific community.
Anti-TMEM119 antibody - C-terminal (ab185333) has 7 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM119 also known as transmembrane protein 119 plays a role in cell membrane dynamics. It has a molecular mass of approximately 35 kDa. TMEM119 is specifically expressed in microglia in the central nervous system. Microglia serve essential functions in brain homeostasis and immune response. Given its expression profile TMEM119 serves as a marker to identify microglia especially in research focused on neurological tissues. Researchers often utilize techniques like microglial flow cytometry and microglial staining for identification and quantification of microglial populations often in frozen marker studies.
Biological function summary
TMEM119 regulates signaling pathways that maintain microglial identity and function but does not typically form part of larger complexes. It modulates microglial activation states and influences responses to central nervous system injury and inflammation. As a membrane protein it may interact with other surface molecules although specific binding partners are not well-characterized in current literature. Researchers value TMEM119 as a reliable marker in studies aiming to distinguish brain-resident microglia from infiltrating peripheral macrophages.
Pathways
TMEM119 functions as a modulator within inflammatory and neuroimmune pathways. It plays roles in the NF-kB signaling and the neuroinflammatory cascade. Its relationship with proteins like CD68 and Iba1 indicates it may influence pathways tied to immune responses and phagocytosis within nervous system contexts. Understanding the interactions and co-expression of TMEM119 with these proteins helps clarify its contribution to neuroimmune functions.
TMEM119 links with neurological conditions such as Alzheimer's disease and multiple sclerosis. Altered expression of TMEM119 appears in disease states potentially contributing to pathogenesis through disrupted inflammatory responses. Its association with proteins such as TREM2 in Alzheimer's suggests that TMEM119 may play indirect roles in the progression of neurodegeneration. Furthermore high TMEM119 levels in pathological samples provide insights into microglial involvement in disease progression and potential targets for therapeutic interventions.