Abcam, ab185345, Anti-AP-Q antibody

Size: 100µL
Rabbit Polyclonal AP-Q antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LVRN aa 800-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LVRN aa 800-950. The exact immunogen used to generate this antibody is proprietary information.Q6Q4G3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AP-Q also known as aminopeptidase Q is a metallopeptidase enzyme involved in the trimming of peptides at the amino terminus. Its molecular mass approximates 110 kDa. This protein is part of the M1 family of aminopeptidases and exhibits specificity for certain peptide substrates. AP-Q expression occurs in various tissues including the kidneys liver and small intestine where it plays a role in protein digestion and metabolism.
Biological function summary
AP-Q is important for regulating peptide hormone activity by processing signaling peptides. It exists as part of a larger peptide-hydrolyzing complex in cellular environments interacting with other enzymes to modulate peptide chains' length and activity. By breaking down bioactive peptides AP-Q influences physiologic processes like blood pressure regulation and immune responses. Its enzymatic activity contributes to maintaining homeostasis through controlled degradation of functional peptides.
Pathways
AP-Q integrates into critical biological processes such as the renin-angiotensin system and antigen processing pathways. In the renin-angiotensin system AP-Q helps regulate blood pressure by controlling the generation of active angiotensin peptides. Related proteins in these pathways include angiotensin-converting enzyme (ACE) which similarly processes peptide substrates to maintain cardiovascular function and fluid balance. By operating within these pathways AP-Q ensures that peptide levels are balanced to sustain normal physiological conditions.
Researchers have linked AP-Q to hypertension and immune system dysfunctions. Anomalies in its enzyme activity may contribute to hypertension through improper regulation of peptide hormones that control vascular resistance. AP-Q also affects immune responses by manipulating antigen presentation processes which can relate to autoimmune disorders or immune deficiencies. Proteins like ACE already known for their role in hypertension often connect with AP-Q in these pathological contexts thereby contributing to or mitigating disease outcomes.