Abcam, ab185979, Anti-Lens Fiber Cell Marker antibody [ZL-1]

Size: 100µg
Mouse Monoclonal Lens Fiber Cell Marker antibody. Suitable for IHC-Fr, IHC-P and reacts with Zebrafish samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:ZL-1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Zebrafish,
Applications:IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
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Properties and Storage Information:
Form-Liquid, Purity-undefined SDS-PAGE, Purification notes-The purity of ab185979 is near homogeneity, as judged by SDS-PAGE. ab185979 was produced in vitro using hybridomas grown in serum-free medium, and then concentrated by chemical fractionation., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The lens fiber cell marker also known as fiber marker or lens marker refers to specific proteins expressed in the lens fiber cells of the eye. A prominent example of such proteins is crystallin which has variants like α-crystallin β-crystallin and γ-crystallin. These proteins tend to have a high molecular mass typically ranging between 20 to 30 kDa. They are expressed predominantly in the lens fiber cells which are critical components of the eye's lens structure and ensure transparency and proper light refraction.
Biological function summary
The lens fiber cell marker proteins play an important role in maintaining lens transparency and flexibility. These proteins commonly exist as part of larger protein complexes that act to prevent protein aggregation ensuring the lens remains clear. Crystallins for example function as molecular chaperones preventing the denaturation and aggregation of other proteins under stress thereby preserving the functionality of the lens. Their stability under different conditions contributes to the long-term clarity and focus of the lens integral for proper vision.
Pathways
Lens fiber cell marker proteins are involved in pathways that regulate protein homeostasis and stress response including the unfolded protein response and oxidative stress pathways. These pathways often involve interactions with other stress-related proteins like heat shock proteins which assist in maintaining cellular and protein stability under thermal or oxidative stress. The capability of crystallins to interact within these pathways highlights their importance in protecting lens integrity and function throughout the individual's lifespan.
Disturbances involving lens fiber cell marker proteins can lead to common lens-related conditions such as cataracts and presbyopia. Cataracts for instance arise when crystallins aggregate and cause lens opacity disrupting vision. These markers are connected to other proteins like connexins which if malfunctioning may also contribute to cataract formation due to impaired intercellular communication in the lens. Understanding the role of these proteins and their pathways can aid in developing therapeutic strategies for eye conditions that impair vision quality.