Abcam, ab186744, Anti-Claudin 17 antibody [EPR15483]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Claudin 17 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15483,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Claudin 17 also known as CLDN17 is a member of the claudin family of proteins essential for the formation of tight junctions in epithelial cells. Weighing approximately 24 kDa Claudin 17 plays a mechanical role in regulating paracellular transport which means it controls the flow of molecules between cells. Expression of this protein occurs mainly in the kidney and liver epithelia where it contributes to the barrier function of these tissues.
Biological function summary
Claudin 17 functions to maintain the selective permeability of epithelial barriers. It is part of the tight junction complex a group of proteins that includes other claudins occludin and junctional adhesion molecules. This complex ensures that tissues maintain homeostasis by controlling the diffusion of solutes and ions across epithelial layers. Claudin 17 also contributes to the polarity and differentiation of epithelial cells impacting how these cells interact with their environment.
Pathways
Researchers have identified Claudin 17 as an important player in the regulation of the paracellular transport pathway and its involvement in maintaining the epithelial barrier function. It participates in pathways that involve sodium and chloride ion transport closely interacting with proteins like Claudin 8 and Claudin 1. Such interactions balance ion transport and cellular permeability important for proper epithelial function.
Researchers have explored Claudin 17's involvement in conditions such as electrolyte imbalance and kidney dysfunction. Its altered expression has been connected to Claudin 3 in renal disorders impacting tight junction integrity. Misregulation could lead to disruptions in ion balance contributing to disease progression. Understanding how Claudin 17 relates to these conditions can drive advancements in therapeutic strategies against epithelial barrier-related diseases.