Abcam, ab187119, Anti-Claudin 6 + Claudin 9 antibody [YD9H8]

Size: 100µg
Rat Monoclonal Claudin 6 antibody. Carrier free. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human CLDN6.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:YD9H8,
Isotype:IgG2b,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human CLDN6.P56747

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Claudin 6 and Claudin 9 are integral membrane proteins that function as key components of tight junctions acting mechanically to regulate the paracellular barrier permeability in epithelial cells. These proteins which weigh approximately 23 kDa and 22 kDa respectively form networks that control the passage of ions and small molecules in tissue barriers. Claudin 6 (also known as CLDN6) is expressed in various tissues during embryonic development but shows limited presence in adult tissues. Claudin 9 (also recognized by its gene name CLDN9) displays expression in inner ear cells and other specific epithelial regions.
Biological function summary
These proteins help maintain tissue integrity by creating selective barriers that influence ion selectivity and cellular polarity. Claudin 6 and Claudin 9 are part of larger tight junction complexes that include other claudin family members and associated proteins like occludin and ZO-1. These complexes are essential for maintaining the proper function of epithelial and endothelial tissues ensuring that cells coordinate efficiently in forming structured tissue layers.
Pathways
The engagement of Claudin 6 and Claudin 9 in tight junction pathways impacts epithelial barrier processes and various signaling pathways. They play roles in the regulation of epithelial cell migration and proliferation through connections to proteins such as ZO-1 and influence signal transduction cascades like the Wnt/β-catenin pathway. These interactions highlight their significances in maintaining homeostasis and responding to physiological stimuli.
Alterations in Claudin 6 and Claudin 9 expression or function associate with conditions like cancer and hearing loss. Dysregulation of Claudin 6 has been linked to several cancers affecting tumor progression and metastasis often interacting with proteins such as E-cadherin. Claudin 9’s role in hearing connects to its function in maintaining the ion balance within the cochlea and malfunction can result in nonsyndromic hearing loss possibly in conjunction with other tight junction proteins like claudin 14.