Abcam, ab187157, Anti-CD1E antibody [EPR15746(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CD1E antibody. Suitable for IHC-P, WB and reacts with Rat, Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15746(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD1E also known as CD1e is a member of the CD1 family of glycoproteins. It has a molecular mass of approximately 37 kDa. CD1E is expressed mainly in the endosomes of antigen-presenting cells such as dendritic cells and macrophages. It plays an essential role in lipid antigen processing inside the cells. By facilitating the presentation of lipid antigens to T cells CD1E helps modulate immune responses.
Biological function summary
CD1E functions as part of a larger protein complex involved in the immune system. In its role it assists in the sorting and processing of lipid antigens derived from various pathogens and endogenous sources. This activity promotes the presentation of these antigens on the cell surface enabling them to be recognized by CD1-restricted T cells. Such interactions are important for developing adaptive immune responses.
Pathways
CD1E participates in antigen processing and presentation pathways which are necessary for immune surveillance. It works closely with other CD1 family members like CD1a and CD1b to ensure the diverse display of lipid antigens to T cells. This collaboration is critical for initiating T cell-mediated immune responses against lipid-based antigens bridging innate and adaptive immunity.
CD1E has been linked to the progression and pathogenesis of certain autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Dysfunction in the CD1E-mediated antigen processing pathway may lead to improper immune activation and self-reactivity. Additionally CD1E is associated with infectious diseases such as tuberculosis where it could interact with Mycobacterium tuberculosis lipids. Proteins like CD1b can influence CD1E function during these disease processes impacting the overall balance of immune responses.