Abcam, ab187291, Anti-Estrogen Receptor beta 1 antibody [ERb455] - C-terminal

Size: 500µL
Mouse Monoclonal ESR2 antibody. C-terminal. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ESR2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:ERb455,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ESR2. The exact immunogen used to generate this antibody is proprietary information.Q92731,
Specificity:Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-ab187291 was purified from Bioreactor concentrate., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The estrogen receptor beta 1 also known as ERβ or NR3A2 is a type of nuclear hormone receptor. It plays a role in modulating gene expression in response to estrogens. ERβ has an approximate mass of 59 kDa and is expressed in a variety of tissues including the ovary prostate and brain. It differs from estrogen receptor alpha (ERα) in terms of distribution and function within the body.
Biological function summary
Estrogen receptor beta 1 functions as a transcription factor modulating various gene expressions in response to estrogen binding. It forms a complex with coactivators or corepressors to regulate its activity. ERβ is known for balancing the proliferative effects that ERα often promotes thereby maintaining cellular homeostasis in various tissues. It contributes to processes like bone density maintenance lipid metabolism and neural differentiation.
Pathways
The activity of estrogen receptor beta 1 is integrated into the estrogen signaling pathway. It interacts with proteins such as ERα and other nuclear receptors to mediate hormonal responses. This receptor is also part of the MAPK pathway which is important for cell proliferation and differentiation. The balance between ERβ and ERα signaling pathways is key for cellular response to estrogens influencing various physiological outcomes.
Estrogen receptor beta 1 has associations with conditions such as breast cancer and osteoporosis. A decreased ratio of ERβ to ERα often links to more aggressive forms of breast cancer where ERβ acts as a counterbalance to the proliferative signals of ERα. In osteoporosis ERβ’s role in bone density can impact disease progression especially when estrogen levels fluctuate post-menopause. Understanding the balance between ERβ and ERα in these diseases could be useful in developing targeted ERβ activators or inhibitors as therapeutic strategies.