Abcam, ab188043, Anti-HOXC13 antibody

Size: 100µL
Rabbit Polyclonal HOXC13 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC13 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXC13 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.P31276

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXC13 also known as Homeobox protein Hox-C13 is a transcription factor belonging to the homeobox gene family. This protein plays a significant role in regulating gene expression influencing cellular proliferation and differentiation. HOXC13 has a mass of approximately 37 kDa and is expressed in specific tissues including hair follicles the skin and certain regions of the central nervous system. The protein contains a homeodomain which allows it to bind DNA and control the transcription of genes essential for proper development.
Biological function summary
HOXC13 influences the development and maintenance of hair and skin by regulating the expression of keratin genes. As a member of the homeobox gene complex it contributes to the establishment of body plans during embryonic development. HOXC13 acts not alone but as part of transcriptional complexes that modify expression patterns of target genes ensuring proper structural attributes of tissues. Its activity impacts cellular differentiation impacting phenotypic characteristics such as hair texture and skin structure.
Pathways
HOXC13 plays a role in the Wnt signaling pathway and epidermal differentiation processes. It interacts with other HOX proteins such as HOXC8 and HOXD13 contributing to the regulation of gene networks involved in skin and appendage formation. These pathways dictate cellular fate ensuring coordinated development and function of keratinocytes in the epidermis as well as hair follicle morphogenesis and cycling.
Alterations in HOXC13 expression or function have been associated with ectodermal dysplasia and hair abnormalities. Mutations or dysregulation of this protein disrupt normal hair and skin development often leading to phenotypes of clinical importance like hypotrichosis. HOXC13 has been implicated in ectodermal dysplasias through its regulatory relationships with genes responsible for keratin synthesis highlighting its importance in integumentary system anomalies.