Abcam, ab188075, Anti-TCFL5 antibody

Size: 100µL
Rabbit Polyclonal TCFL5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TCFL5 aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TCFL5 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q9UL49

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCFL5 also known as Transcription Factor Like 5 is a protein involved in transcription regulation. It has a molecular mass of approximately 52 kDa. TCFL5 is mainly expressed in testes indicating a significant role in reproductive biology. The protein functions as a sequence-specific DNA-binding factor which helps regulate transcription of specific genes critical for spermatogenesis.
Biological function summary
TCFL5 acts as an important regulator during spermatogenesis influencing the development of male germ cells. The protein is likely involved in a transcription factor complex enabling precise control over the expression of genes needed for germ cell maturation. Proper functioning of TCFL5 is important for healthy sperm production and overall fertility.
Pathways
TCFL5 plays a role in the spermatogenesis pathway. It interacts with other transcription factors and proteins such as SOX and GATA ensuring regulated differentiation of germ cells. This process is part of gametogenesis a broader biological pathway that describes the formation and development of gametes. TCFL5 helps orchestrate the precise timing and expression of genes necessary for this complex biological process.
TCFL5 dysregulation has been linked to certain male infertility problems. Aberrant TCFL5 expression or mutation can disrupt the normal process of spermatogenesis leading to issues such as azoospermia. Researchers also study its interactions with proteins like PIWI which are involved in maintaining germline integrity to better understand the molecular underpinnings of these fertility disorders.