Abcam, ab188329, Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TXNDC11/EFP1 antibody. C-terminal. Suitable for IP, WB and reacts with Human, Rat, Mouse samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14314,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Based on the sequence analysis, ab188329 recognizes 2 isoforms with the predicted MWs of 111KDa and 108KDa, respectively.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TXNDC11 also known as EFP1 is a thioredoxin domain-containing protein with a molecular mass of approximately 119 kDa. This protein acts as a disulfide isomerase involved in protein folding and redox regulation. TXNDC11 localizes mostly in the endoplasmic reticulum where its expression helps maintain cellular redox homeostasis. Recent studies also indicate expression in various tissues which suggests a role in broader cellular mechanisms.
Biological function summary
The redox regulation function of TXNDC11 contributes to the maturation and stabilization of nascent proteins. It appears to interact with other proteins in a complex manner to facilitate these processes. TXNDC11 mediates the formation and rearrangement of disulfide bonds serving as a chaperone that assists in proper protein folding which is essential for maintaining cell function and viability.
Pathways
TXNDC11 integrates into the protein processing pathways within the endoplasmic reticulum. It plays a role in the unfolded protein response (UPR) pathway important for managing ER stress. Proteins such as BiP/GRP78 and protein disulfide isomerase (PDI) work in conjunction with TXNDC11 to ensure proper protein folding under stress conditions highlighting its pathway integration.
TXNDC11's malfunction or misexpression links to diseases involving protein misfolding such as neurodegenerative disorders and certain cancers. Its roles in redox mechanisms and ER stress responses also connect it to insulin resistance syndromes. Interactions with proteins like IRE1 and CHOP suggest a significant role in these pathological conditions making it a potential target for therapeutic research.