Abcam, ab188330, Anti-POC5 antibody [EPR14000-76] - N-terminal

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal POC5 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14000-76,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
POC5 also known as Proteome of Centriole 5 is a protein encoded by the POC5 gene. The POC5 protein has a molecular mass of about 63 kDa. It is expressed in various tissues with high expression levels noted in the testis and brain. POC5 localizes to the centrioles which are key structures within the centrosome involved in the formation of cilia and flagella essential for cellular movement and organization.
Biological function summary
POC5 contributes to the maintenance and function of centrioles. It forms part of a complex that stabilizes the structure of centrioles ensuring correct centrosome duplication and cycle progression. By maintaining centriole integrity POC5 supports proper cell division and ensures that chromosomal segregation proceeds without errors during mitosis preserving genomic stability.
Pathways
POC5 integrates into the centrosome duplication pathway and the regulation of the cell cycle. It interacts with other proteins including CEP63 and PLK4 to ensure robust centriole duplication and prevent errors during cell cycle phases. POC5 therefore has an essential role in centrosome-related pathways which govern critical aspects of cell division and replication.
POC5 has been linked to ciliopathies and certain cancers like retinal degeneration and colorectal cancer. In ciliopathies impaired POC5 function disrupts the normal formation and stability of cilia causing defects that can lead to disease. Connections with proteins such as CEP290 in retinal degeneration highlight POC5's involvement in maintaining ciliary function. Increased or altered expression of POC5 in cancer has been observed suggesting its potential role as an oncogenic factor through disrupting normal centrosome function and chromosomal integrity.