Abcam, ab188575, Anti-NDUFB7 antibody [EPR15903]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NDUFB7 antibody. Suitable for IP, Flow Cyt, WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15903,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, Flow Cyt, WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFB7 also known as NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 plays a significant mechanical role in the mitochondrial electron transport chain. It is a small protein with a molecular mass of approximately 11.5 kDa. This protein is found in the mitochondria and is expressed across various tissues throughout the human body. As part of a larger complex it contributes to the function of Complex I in the respiratory chain.
Biological function summary
NDUFB7 is an integral component of Complex I (NADH: ubiquinone oxidoreductase) which is an important player in cellular respiration. Complex I forms part of the mitochondrial inner membrane and is important for the biochemical process of converting NADH-derived electrons and protons into a proton gradient across the membrane. Although not directly involved in the catalytic process NDUFB7 is essential for the proper assembly and stability of Complex I influencing its overall performance.
Pathways
NDUFB7 is deeply involved in the oxidative phosphorylation pathway which is critical for ATP production in aerobic respiration. It also plays a role in the mitochondrial dysfunction pathway often associated with neurodegenerative diseases. Other proteins such as NDUFS1 and NDUFV1 also belong to Complex I and work alongside NDUFB7 in these pathways to maintain energy homeostasis in cells.
Mutations or dysfunctions in NDUFB7 have been linked to mitochondrial diseases particularly Leigh syndrome which is a severe neurological disorder. The protein’s malfunction negatively impacts energy production in neurons leading to their degeneration. Additionally NDUFB7’s involvement in oxidative phosphorylation connects it to myopathies characterized by mitochondrial defects. Proteins related to these conditions include other core subunits of Complex I like NDUFA9 which also exhibit alterations in such disease states.