Abcam, ab188615, Anti-ARPP-19 antibody

Size: 100µL
Rabbit Polyclonal ARPP-19 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human cAMP-regulated phosphoprotein 19 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human cAMP-regulated phosphoprotein 19 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P56211

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARPP-19 also known as cAMP-regulated phosphoprotein 19 is a protein that plays an important role in cellular processes. The protein has a molecular weight of approximately 19 kDa. Its expression can be found in various tissues with significant levels detected in the brain. ARPP-19 undergoes phosphorylation which is essential for its activity in cellular signaling.
Biological function summary
ARPP-19 influences cell cycle regulation and neuronal signaling. The protein does not appear to be part of a larger protein complex. It interacts with protein phosphatase 2A (PP2A) modulating its activity during mitosis. This regulation helps ensure proper cell division and function. The protein also shows involvement in neurodevelopmental pathways contributing to brain development and function.
Pathways
The involvement of ARPP-19 includes regulation within the cAMP signaling pathway and the mitotic spindle assembly checkpoint. It interacts with proteins like PP2A and Greatwall kinase coordinating the phosphorylation status of key mitotic substrates. ARPP-19 affects the transition from interphase to mitosis impacting the signaling cascade that controls this phase.
ARPP-19 has associations with cancer and neurodegenerative diseases. Aberrant phosphorylation of ARPP-19 and related proteins like PP2A can lead to mitotic errors promoting oncogenesis. In neurodegenerative contexts altered ARPP-19 function may affect neuronal signaling and plasticity contributing to conditions such as Alzheimer's disease. Understanding these interactions helps in exploring therapeutic strategies targeting these specific pathways.