Abcam, ab189878, Anti-GnRH antibody

Size: 100µL
Rabbit Polyclonal GnRH antibody. Suitable for WB and reacts with Recombinant full length protein - Human, Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GNRH1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GNRH1.P01148

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gonadotropin-releasing hormone (GnRH) also referred to as luteinizing hormone-releasing hormone (LHRH) or gonadotropin peptide is a small peptide hormone with a molecular weight of approximately 1.2 kDa. GnRH is chiefly expressed in the hypothalamic neurons located in the pre-optic area of the brain. It is synthesized as a preprohormone and undergoes cleavage to become its active form. GnRH plays an important role in the regulation of reproductive functions acting as an important regulator of the release of pituitary gonadotropins.
Biological function summary
GnRH influences reproduction by stimulating the anterior pituitary gland to secrete two essential gonadotropins: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These gonadotropins further act on the gonads to promote steroidogenesis and gametogenesis essential processes for fertility. The GnRH peptide hormone does not typically form part of a larger protein complex. Instead it interacts directly with specific receptors on the surface of anterior pituitary cells to carry out its functions.
Pathways
The gonadotropin peptide acts within the hypothalamic-pituitary-gonadal (HPG) axis an integral pathway for maintaining reproductive health and hormonal balance. This pathway involves GnRH LH FSH and steroid hormones like estradiol and testosterone. In the HPG axis GnRH release is subjected to feedback mechanisms from the steroid hormones ensuring the fine-tuning of reproductive hormone levels. Additionally this peptide is part of the neuroendocrine control pathway interacting with other neuropeptides like kisspeptin which modulates its secretion thereby influencing overall reproductive function.
Dysfunctions in GnRH signaling can lead to conditions such as hypogonadotropic hypogonadism and precocious puberty. These disorders result from insufficient or excessive release of gonadotropins due to impaired GnRH action. In hypogonadotropic hypogonadism there is a failure in stimulation of LH and FSH leading to inadequate sex steroid production and subsequent infertility or delayed puberty. Conversely excessive GnRH activity may result in precocious puberty where early activation of the reproductive axis occurs. Anti-GnRH therapies aim to modulate these dysfunctions aligning related proteins like kisspeptin and neurokinin B with therapeutic approaches.