Abcam, ab189923, Anti-C10orf35 antibody [EP14950-82]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C10orf35 antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP14950-82,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C10orf35 also known as Chromosome 10 Open Reading Frame 35 encodes a protein with a mass of approximately 86 kDa. This protein primarily localizes to the cytoplasm and shows significant expression in various tissues including the testis brain and heart. Its exact mechanical role remains not fully understood but it is suggested to be involved in cellular processes related to structural organization.
Biological function summary
C10orf35 interacts with cellular components often associated with maintaining cellular architecture and signaling pathways. It does not typically form part of well-defined protein complexes yet it still contributes to the integrity and function of specialized cells. The expression pattern hints at a mechanism influencing cell differentiation and proliferation particularly in reproductive and neural tissues.
Pathways
Researchers have linked C10orf35 to significant cellular signaling and development pathways including the Wnt/β-catenin signaling pathway and the Hedgehog signaling pathway. These pathways play critical roles in cell fate determination and embryonic development. C10orf35 shows interaction with proteins like β-catenin and Hedgehog influencing downstream signaling events critical for transcriptional regulation and morphogenetic processes.
Researchers investigated the involvement of this target in developmental disorders and cancers particularly testicular cancer. The malfunction or abnormal expression of C10orf35 can disrupt cellular homeostasis leading to uncontrolled cell proliferation and differentiation. Its interaction with β-catenin is particularly notable in cancer-related research suggesting potential as a therapeutic target for modulating oncogenic pathways.