Abcam, ab190283, Anti-UBQLN2 antibody [6H9]

Size: 100µL
Mouse Monoclonal UBQLN2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UBQLN2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:6H9,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UBQLN2. The exact immunogen used to generate this antibody is proprietary information.Q9UHD9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.03% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBQLN2 also known as ubiquitin-like protein UBQLN2 or ubiquilin-2 functions as part of the ubiquitin-proteasome system. It helps in shuttling ubiquitinated proteins to the proteasome for degradation. UBQLN2 has a molecular mass of approximately 66 kDa. Diverse tissues express UBQLN2 including brain kidney and skeletal muscle indicating its widespread importance in various cellular processes.
Biological function summary
UBQLN2 interacts with other proteins involved in protein quality control. It participates in complexes that manage protein homeostasis by assisting in the degradation of misfolded or damaged proteins. This action prevents the accumulation of toxic protein aggregates. UBQLN2's role in the cellular protein degradation pathway highlights its importance in maintaining cellular function and integrity.
Pathways
UBQLN2 engages in the endoplasmic reticulum-associated degradation (ERAD) pathway which ensures the elimination of misfolded proteins from the ER. It also links to the autophagy-lysosome pathway. UBQLN2 interacts with VCP/p97 in these pathways an important protein that assists in extracting ubiquitinated proteins for degradation. Through these interactions UBQLN2 contributes a pivotal role in maintaining cellular homeostasis.
Researchers have linked UBQLN2 mutations to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Abnormalities in UBQLN2 may lead to the accumulation of protein aggregates harmful to neuronal cells. Connections between UBQLN2 and other proteins such as TARDBP (TDP-43) further emphasize its relevance as TDP-43 pathology is common in these neurodegenerative disorders. Understanding UBQLN2's function provides insight into potential therapeutic targets for these diseases.