Abcam, ab190360, Anti-UQCRB antibody [EPR15591]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal UQCRB antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15591,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UQCRB also known as ubiquinol-cytochrome c reductase binding protein is an important component of the mitochondrial electron transport chain specifically within the complex III (or cytochrome bc1 complex) of mitochondria. This protein has a molecular mass of approximately 14 kDa. It is localized in the inner membrane of mitochondria and is expressed in various tissues with high energy demands such as the heart liver and muscle tissues. UQCRB plays a significant mechanical role in transporting electrons from ubiquinol to cytochrome c a critical step in cellular respiration.
Biological function summary
The ubiquinol-cytochrome c reductase binding protein participates in facilitating efficient electron transfer within complex III. As a constituent of the cytochrome bc1 complex UQCRB contributes to the formation of a proton gradient across the mitochondrial membrane which is necessary for the production of ATP. This process is part of oxidative phosphorylation the principal pathway for energy generation in eukaryotic cells. UQCRB interacts closely with other components of the complex III such as cytochrome b and cytochrome c1 ensuring proper electron flow and energy transduction.
Pathways
UQCRB has a pronounced role in the oxidative phosphorylation pathway. This pathway is fundamental in the synthesis of ATP the energy currency in cells through the chemiosmotic coupling of electron transport and phosphorylation. UQCRB serves as a bridging protein for the coherent transfer of electrons from NADH:ubiquinone oxidoreductase (complex I) and succinate dehydrogenase (complex II) towards the cytochrome c oxidase (complex IV). It is intricately linked to other mitochondrial proteins like cytochrome c and ATP synthase that play roles in energy conversion and utilization.
UQCRB is associated with mitochondrial disorders specifically with mitochondrial complex III deficiency. This condition has been implicated in various pathologies including Leigh syndrome a severe neurological disorder. Mutations in the UQCRB gene can impair electron transport leading to insufficient ATP production and increased production of reactive oxygen species which contribute to cellular damage. UQCRB's association with other components of complex III such as cytochrome b may exacerbate these deficiencies and highlight its potential as a therapeutic target for mitochondrial dysfunction-related diseases.