Abcam, ab190718, Anti-CEACAM1 + CEACAM5 antibody [C66/261]

Size: 50µL / 500µL
Mouse Monoclonal CEAM1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CEACAM5.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C66/261,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CEACAM5.P06731

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM1 and CEACAM5 are members of the carcinoembryonic antigen (CEA) family also referred to as CD66a and CD66e respectively. CEACAM1 with a molecular weight of approximately 120 kDa and CEACAM5 weighing around 200 kDa serve as cell surface glycoproteins. They localize primarily on epithelial cells and are also expressed in immune cells such as neutrophils and lymphocytes. These proteins mediate intercellular interactions and play roles in cell adhesion and signaling.
Biological function summary
These CEACAM proteins modulate immune responses and maintain epithelial tissue architecture. CEACAM1 acts as a regulator of immune cell signaling and participates in microbial recognition. It is part of complexes with other signaling molecules due to its cytoplasmic domain that interacts with intracellular adaptors. CEACAM5 enhances cell adhesion and is important for maintaining cellular integrity.
Pathways
CEACAM1 and CEACAM5 participate in immune and signaling pathways. CEACAM1 modulates the PI3K-Akt pathway influencing cell proliferation and survival. It associates closely with proteins such as SHP-1 and SHP-2 which act as phosphatase regulators. CEACAM5 is involved in the MAPK pathway which influences cell growth regulation and is linked to cellular responses to external stimuli.
CEACAM1 and CEACAM5 are associated with cancer and inflammatory diseases. CEACAM5 is a known biomarker for colorectal cancer where it can be overexpressed leading to tumor progression. CEACAM1 correlates with melanoma as its expression levels can affect tumor immune evasion. Both proteins are targets for therapeutic interventions in cancer interacting with immune checkpoint molecules like PD-1 in tumor environments.