Abcam, ab190794, Anti-PWP1 antibody [EPR16130]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PWP1 antibody. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16130,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PWP1 protein also known as Periodic tryptophan protein 1 homolog is a 90 kDa nuclear protein that participates in the assembly of ribosomal subunits. It is predominantly expressed in the nucleolus and is part of the WD40 protein family characterized by repeating units that form a β-propeller structure. This structure facilitates its interaction with various molecular partners allowing it to play a role in ribosome biogenesis.
Biological function summary
PWP1 is involved in the nucleolar function and ribosome production. It acts as part of a multiprotein complex that assists in the maturation of pre-ribosomal particles. The protein contributes to the processing and assembly of ribosomal RNA ensuring proper ribonucleoprotein configuration. This function is especially important in regulating gene expression by controlling protein synthesis at the ribosomal level.
Pathways
PWP1 is a component of the ribosome biogenesis pathway which integrates its activity with other proteins such as NOP58 and RRP9. It is also linked to the RNA processing pathway where it interacts with other nucleolar proteins to ensure accurate RNA transcription and modification. These pathways are essential for maintaining cellular homeostasis and responding to growth signals impacting cell proliferation.
PWP1's dysfunction has connections with cancer and disorders relating to ribosomal dysregulation. Aberrant expression or mutation of PWP1 may lead to disruptions in ribosomal biogenesis contributing to oncogenesis. The protein is associated with abnormal regulatory networks alongside proteins like NPM1 which also plays a role in tumorigenesis. Investigations into PWP1 offer insights into potential biomarkers and targets for therapeutic intervention in ribosome-related diseases.