Abcam, ab190819, Anti-Adrenomedullin/ADM antibody

Size: 100µL
Rabbit Polyclonal Adrenomedullin/ADM antibody. Suitable for WB and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ADM aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADM aa 50-150. The exact immunogen used to generate this antibody is proprietary information.P35318

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab190819 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The adrenomedullin (ADM) protein alternatively known as protein n20 is a peptide hormone with a mass of approximately 6 kilodaltons. It is mainly expressed in the adrenal medulla but you can also find it in various tissues including the heart lungs and kidneys. ADM is involved in multiple physiological processes operating as a vasodilator and playing a role in blood pressure regulation. The presence of ADM in endothelial and smooth muscle cells emphasizes its role in vascular function.
Biological function summary
Adrenomedullin contributes to homeostasis and cellular growth. It is not a part of a complex but interacts with specific receptors like the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). These interactions activate signaling cascades that contribute to mitogenesis and angiogenesis highlighting ADM's role in cellular protection and tissue repair. ADM's activity extends to immune modulation and fluid-electrolyte balance.
Pathways
Adrenomedullin shows involvement in signaling pathways like the cAMP and MAPK pathways. It interacts closely with proteins such as RAMP2 and RAMP3 which define its receptor heterodimers in a tissue-dependent manner. ADM influences cellular responses by promoting vasodilation and modulating inflammatory responses fitting integrally into vascular homeostasis and immune functions.
ADM relates to cardiovascular and inflammatory diseases. It shows altered expression levels in conditions such as heart failure and sepsis. In these diseases ADM interacts with molecules like endothelin-1 which affect vascular tone and endothelial function. Understanding ADM's role can lead to potential therapeutic strategies targeting its pathways in cardiovascular and inflammatory pathologies.