Abcam, ab190950, Anti-CacyBP antibody

Size: 100µg
Rabbit Polyclonal CacyBP antibody. Suitable for IP, ICC/IF, WB, Flow Cyt and reacts with Human, Rat, Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CACYBP aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IP, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CACYBP aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q9HB71

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.06% Sodium azide, 0.06% Thimerosal (merthiolate)Constituents: 30.83% BSA, 5.55% Sodium chloride, 1.23% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CacyBP also known as Calcyclin Binding Protein is involved in various cellular processes and interactions. This protein has a molecular mass of about 30 kDa. It is broadly expressed in many tissues including the brain where it plays significant roles. CacyBP interacts with several other proteins impacting cellular structures and functions through complex interactions.
Biological function summary
CacyBP regulates key cellular functions by interacting with signaling pathways and cytoskeletal elements. It can form part of multi-protein complexes influencing the stability and structure of cytoskeletal components. CacyBP also modifies proteins by dephosphorylation impacting processes such as cell division and differentiation. These functions underline its involvement in cellular maintenance and dynamic processes.
Pathways
CacyBP participates in cellular signaling and protein degradation pathways. It plays a role in the ubiquitin-proteasome pathway by mediating the degradation of specific substrate proteins. This protein associates with Siah-1 an E3 ubiquitin-protein ligase emphasizing its function in this pathway. CacyBP is also linked to ERK1/2 signaling pathways interacting with proteins like ERK2 to modulate cell proliferation and differentiation.
CacyBP has connections to cancer and neurodegenerative diseases. In cancer CacyBP influences tumor growth and progression by affecting cell cycle regulation and apoptosis. It interacts with proteins such as p53 which play roles in cell cycle control and tumor suppression. In neurodegenerative diseases like Alzheimer's altered CacyBP expression levels have been observed implicating it in the disorder’s pathology through interactions with tau protein.