Abcam, ab192032, Anti-TRIM23/ARD1 antibody [EPR7787]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRIM23/ARD1 antibody. Suitable for WB and reacts with Rat, Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7787,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM23 also known as ARD1 is a protein with an approximate mass of 77 kDa. It belongs to the tripartite motif (TRIM) family which is characterized by the presence of a RING finger domain a B-box domain and a coiled-coil region. TRIM23/ARD1 is expressed in various tissues including the heart and skeletal muscle. Its role as an E3 ubiquitin ligase is vital as it facilitates the ubiquitination and proteasomal degradation of specific substrates contributing to protein homeostasis within cells.
Biological function summary
TRIM23/ARD1 plays a role in immune and inflammatory responses. It participates in the maturation of autophagosomes a process that is essential for cellular repair and stress responses. Rather than functioning independently TRIM23/ARD1 associates with complex cellular systems including the endosomal-lysosomal pathway influencing the degradation and recycling of cellular components.
Pathways
TRIM23/ARD1's activity is integral to the autophagy and NF-kB signaling pathways. In the autophagy pathway TRIM23/ARD1 acts alongside proteins like ULK1 regulating autophagosomal formation and turnover. Within the NF-kB signaling pathway TRIM23/ARD1 modulates transcription factors that respond to inflammation and stress. Through these pathways TRIM23/ARD1 influences cellular responses to environmental stimuli ensuring proper cellular function.
TRIM23/ARD1's malfunctions have associations with cancer and neurodegenerative diseases. Its role in cancer involves the regulation of cell proliferation and apoptosis; disruptions can contribute to tumor growth. In neurodegenerative diseases TRIM23/ARD1 interacts with proteins such as tau impacting protein aggregation and clearance which are critical in diseases like Alzheimer's. Understanding TRIM23/ARD1's interactions in these conditions could provide insights into potential therapeutic targets.