Abcam, ab192517, Anti-NEIL1 antibody

Size: 100µg
Rabbit Polyclonal NEIL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Endonuclease 8-like 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Endonuclease 8-like 1.Q96FI4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purity is > 95% (by SDS-PAGE)., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NEIL1 also known as Nei endonuclease VIII-like 1 functions as a DNA glycosylase involved in base excision repair. This protein has a molecular mass of approximately 44 kDa. NEIL1 operates on oxidatively damaged bases in DNA removing lesions from DNA to maintain genome integrity. Expression of NEIL1 occurs in various tissues with higher levels often found in the liver and other metabolically active organs.
Biological function summary
NEIL1 plays an important role in the DNA damage repair process ensuring stability and integrity of the genome. It is particularly active in removing oxidative damage to bases functioning as part of the base excision repair pathway. NEIL1 works in coordination with other proteins such as DNA polymerase and ligase to repair DNA. It does not exist alone but forms complexes with these and other DNA repair proteins to carry out its role efficiently.
Pathways
NEIL1 acts within the base excision repair and nucleotide excision repair pathways. These pathways are vital for correcting DNA damage caused by oxidative stress and other environmental factors. In these pathways NEIL1 interacts with other repair enzymes including DNA polymerase beta to ensure proper coordination during the repair process. The interaction helps streamline the replacement and sealing of damaged DNA segments.
Alterations in NEIL1 function associate with various conditions specifically cancer and neurodegenerative diseases. Mutations or deficiencies in NEIL1 can lead to improper repair of DNA contributing to carcinogenesis. Moreover research indicates NEIL1 may interact with other proteins like p53 a known tumor suppressor linking its role in tumor development and suppression. In neurodegenerative diseases faulty DNA repair mechanisms involving NEIL1 contribute to neuronal damage and disease progression.