Abcam, ab192616, Anti-UCHL5IP antibody [EPR15341-56]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal UCHL5IP antibody. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15341-56,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:Flow Cyt (Intra), WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UCHL5IP also known as Ubiquitin Carboxyl-terminal Hydrolase L5 Interacting Protein functions as an important protein supporting the role of UCHL5 in protein degradation. UCHL5IP is involved in deubiquitination processes and has closely-related functions with enzymes in removing ubiquitin from proteins. Its molecular mass is approximately 26 kDa. UCHL5IP is broadly expressed in various tissues suggesting its involvement in several cellular processes.
Biological function summary
UCHL5IP regulates protein turnover by assisting the function of UCHL5. It forms part of a complex with the proteasome which is important for maintaining protein homeostasis. This interaction helps the proteasome properly degrade misfolded or excessive proteins enhancing cellular regulation. The involvement of UCHL5IP in maintaining protein quality control underlines its significance in cellular integrity and function.
Pathways
Scientists recognize UCHL5IP's participation in the ubiquitin-proteasome pathway a major cellular mechanism controlling protein degradation. It interacts with UCHL5 a component of the protease interacting with the proteasome. The pathway is responsible for regulating protein levels and maintaining cellular balance. Additionally UCHL5IP might have connections to signaling pathways through roles in modulating protein levels linking it to broader networks of cellular communication and response.
Researchers have linked UCHL5IP to neurodegenerative diseases due to its involvement in proteasome function. Malfunction in protein degradation pathways contributes to disorders such as Parkinson’s disease. UCHL5IP through its interaction with UCHL5 can influence the build-up of misfolded proteins which are necessary for disease development. Continued study on UCHL5IP might provide further insights into its role in these conditions and potential therapeutic targets.