Abcam, ab192758, Anti-Kv1.2 antibody [K14/16]

Size: 100µg
Mouse Monoclonal Kv1.2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat, Mouse samples. Cited in 5 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:K14/16,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv1.2 also known as KCNA2 is a voltage-gated potassium channel subunit with a molecular mass of approximately 65 kDa. It plays a critical role in mediating potassium ion conductance across the cell membrane. Kv1.2 is expressed in the brain particularly in neurons but is also found in heart and other tissues. Its activity is essential for controlling the electrical excitability of cells by contributing to the repolarization phase of the action potential.
Biological function summary
The function of Kv1.2 involves regulating neuronal excitability and signaling. As a member of the wider Kv1 family it often assembles into tetrameric complexes with other Kv1 subunits to form functional channels. These complexes influence the duration and frequency of action potentials impacting synaptic transmission and plasticity which are important for normal nervous system function.
Pathways
Kv1.2 is involved in neuronal signaling pathways and cardiac action potential regulation. In the nervous system its activity affects neurotransmitter release by modulating the repolarization phase of action potentials. In the heart Kv1.2 plays a role in maintaining proper cardiac rhythm through its interaction with other potassium channels including Kv2.1. This interaction helps ensure that electrical signals in the heart and brain move smoothly.
Mutations or dysfunction in Kv1.2 are associated with certain neurological and cardiac conditions. In the nervous system alterations in Kv1.2 activity can contribute to epilepsy a disorder characterized by uncontrolled neuronal firing. In the heart abnormal Kv1.2 function may relate to arrhythmias which involve irregular heartbeats. The protein Kv2.1 which interacts with Kv1.2 also associates with these disorders highlighting the importance of proper channel function in maintaining healthy neurological and cardiac activities.