Abcam, ab192761, Anti-Kv2.1/KCNB1 antibody [K89/34]

Size: 100µg
Mouse Monoclonal Kv2.1/KCNB1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 10 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:K89/34,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Kv2.1 channel also known as KCNB1 is a voltage-gated potassium channel with a mass of approximately 110 kDa. It is important for maintaining the electrical excitability of neurons. Kv2.1 channels are found in the brain specifically within the cortex and hippocampus. They contribute to the regulation of neuronal firing and neurotransmitter release. The presence of these channels influences how neurons respond to stimuli affecting overall neural activity.
Biological function summary
Kv2.1 channels modulate potassium ion flow across the cell membrane contributing to repolarization after neuronal action potentials. These channels form homotetrameric complexes but can also heteromerize with other Kv channels such as Kv8 and Kv9 which alter their biophysical properties. The ability to form diverse channel complexes allows for varied neuronal responses critical for synaptic plasticity and adaptation to different signaling needs.
Pathways
Kv2.1 channels play a role in the regulation of neural activity by participating in the MAPK signaling pathway. This pathway is essential for the transmission of synaptic signals and neuronal survival. Kv2 channels also interact with proteins like calcineurin which influences channel dephosphorylation and activity. Through these interactions Kv2.1 aligns closely with mechanisms controlling neural excitability and response to environmental changes.
Kv2.1 channels are linked with temporal lobe epilepsy and ischemic stroke. Mutations in the KCNB1 gene can alter channel function leading to abnormal neuronal excitability and increased seizure susceptibility. Kv2.1 activity also affects the function of related proteins such as the NMDA receptor which is involved in excitotoxicity during stroke. Understanding Kv2.1's role in these conditions can aid in the development of therapeutic strategies targeting these disorders.