Abcam, ab192771, Anti-AZIN2 antibody

Size: 50µL
Rabbit Polyclonal AZIN2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AZIN2 aa 100-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AZIN2 aa 100-400. The exact immunogen used to generate this antibody is proprietary information.Q96A70

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target AZIN2 also known as Antizyme Inhibitor 2 is a protein that modulates polyamine levels within cells by inhibiting antizyme activity. It weighs approximately 47 kDa. AZIN2 expresses in various tissues including the brain and adrenal glands where its role is closely associated with polyamine biosynthesis. The protein interacts with antizymes to regulate their function which in turn controls the degradation of ornithine decarboxylase and the uptake of polyamines.
Biological function summary
AZIN2 functions as a modulator of the polyamine pathway preventing protein degradation and facilitating cellular growth and proliferation. It is part of a regulatory complex that includes antizymes and affects the homeostasis of polyamines. This complex interplay significantly impacts the cellular environment and plays a role in maintaining cellular function influencing processes such as signal transduction and ion transport.
Pathways
AZIN2's manipulation of the polyamine pathway reveals its role in cellular growth regulation. It participates in the pathway alongside the arginine and proline metabolism influencing the balance of polyamines within cells. AZIN2 shares a relationship with ornithine decarboxylase and antizymes stabilizing polyamine levels critical for DNA stabilization and protein synthesis.
Dysregulation of AZIN2 can relate to cancer and metabolic syndrome. In cancer disrupted polyamine regulation can lead to uncontrolled cell proliferation; AZIN2 affects this through its interaction with antizymes and ornithine decarboxylase. In metabolic syndrome altered polyamine levels associate with energy homeostasis and can implicate AZIN2’s function in disease progression. Understanding these connections provides potential therapeutic avenues for managing such conditions.