Abcam, ab192833, Anti-Pellino 1 + Pellino 2 antibody [EPR19282]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Pellino 1 antibody. Suitable for WB and reacts with Recombinant full length protein - Human, Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19282,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pellino 1 and Pellino 2 are E3 ubiquitin ligases known for their roles in mediating immune responses. Alternate names for Pellino proteins include PEK and PELI. Pellino 1 has a molecular mass of approximately 47 kDa while Pellino 2 has a mass around 45 kDa. These proteins localize mainly in the cytoplasm and nucleus of immune cells such as macrophages and dendritic cells. They participate in transmitting signals from receptors to downstream signaling proteins essential for regulating immune pathways.
Biological function summary
These proteins play significant roles in controlling the TLR/IL-1 signaling pathway. Pellino 1 and Pellino 2 can form complexes with other signaling intermediates like IRAK1 and TRAF6 which are key components in innate immunity. They add ubiquitin molecules to specific target proteins thereby modulating their stability and activity. This ubiquitination process is important in facilitating the proper response to infections.
Pathways
Pellino 1 and Pellino 2 are integral to the NF-kB and MAPK signaling pathways both of which are central to immune response regulation. They interact with proteins like IRAK1 to promote activation of these pathways leading to gene expression necessary for inflammation and defense mechanisms. This regulation ensures that cells mount an appropriate immune response against pathogens and maintain homeostasis.
Impaired function or regulation of Pellino proteins links to autoimmune diseases such as rheumatoid arthritis and inflammatory disorders like Crohn’s disease. These conditions involve inappropriate activation of immune pathways where increased Pellino activity can exacerbate inflammatory responses. Pellino proteins connect with TNF-alpha a cytokine prominent in these disorders highlighting their critical roles in disease modulation.