Abcam, ab192873, Anti-Solo antibody [EPR13772-74]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Solo antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13772-74,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
'Solo' also known as the SQSTM1-like protein is a multi-functional protein with a mass of approximately 62 kDa. It is expressed abundantly in the cytoplasm of various cell types and tissues particularly in muscle and nerve tissues. Solo functions mechanistically by serving as a scaffold protein that interacts with other proteins to regulate cellular processes such as autophagy and signal transduction. Its expression level can vary depending on the cellular context indicating its role in dynamic cellular modulation.
Biological function summary
Solo operates within the context of cellular maintenance and response mechanisms. It acts as an important regulator in autophagic and ubiquitin-proteasome systems often but not always working in conjunction with other proteins to form complexes. Solo modulates the degradation of misfolded proteins and damaged organelles ensuring cellular homeostasis and stress response. Its interactions may influence cellular survival pathways emphasizing Solo's participation in maintaining cellular integrity and normal function.
Pathways
Solo's involvement spans important biological processes such as the autophagy-lysosome pathway and the mTOR signaling pathway. In the autophagy pathway Solo interacts with proteins like LC3 and p62 playing an important role in cargo recognition and transport to lysosomes for degradation. In the mTOR pathway it influences cell growth and proliferation by modulating nutrient sensing and energy balance. Solo's interactions within these pathways highlight its role in regulating cellular metabolism and stress responses.
Solo has been associated with neurodegenerative conditions and muscular dystrophies. In diseases like Alzheimer's Solo's dysregulation can affect protein aggregation and clearance linking it to proteins such as tau and amyloid-beta. In muscular dystrophies alterations in Solo expression and function might impact muscle cell health associating it with dystrophin and related proteins. Understanding Solo's roles in these diseases can provide insights into therapeutic targets and strategies for intervention.