Abcam, ab192882, Anti-PHACTR4 antibody [EP12543]

Size: 100µL
Rabbit Monoclonal PHACTR4 antibody. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP12543,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHACTR4 also known as Phosphatase and Actin Regulator 4 is a protein involved in regulating actin and protein phosphatase 1 (PP1). It has a molecular weight of approximately 78 kDa. It is expressed in various tissues including the brain and heart indicating its significant role in these organs. PHACTR4 influences cytoskeletal organization a critical aspect determining cell shape and function.
Biological function summary
PHACTR4 plays a role in cytoskeleton dynamics and neuron development by interacting with actin filaments and PP1. It is not known to be part of a larger protein complex but it still influences cell migration and polarity through its interactions. PHACTR4 also contributes to embryonic development especially in neural tube formation ensuring proper neural development.
Pathways
PHACTR4 is involved in processes related to cytoskeletal reorganization and cell motility regulation. It interacts with the Wnt signaling pathway which is important for embryonic development and cell differentiation. It also engages with proteins like cofilin which further modulates actin dynamics and cell motility indicating its interconnection with cellular structural pathways.
PHACTR4 has associations with neural tube defects and specific types of cancers. Its regulation of actin dynamics impacts tumor progression and metastasis. Related proteins such as PP1 show involvement in these conditions as well highlighting the network of interactions PHACTR4 engages in which affect disease progression and cellular malfunction particularly within neural and tumoral environments.