Abcam, ab192985, Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade

Size: 100µL / 1mL
Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) is a rabbit monoclonal antibody detecting Histone H3 in Western Blot, IP, IHC-P, ICC/IF, ELISA, ChIP, PepArr . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 50 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18607,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, PepArr, IHC-P, ELISA, ChIP, ChIP-seq, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIP, ChIP-seq, ELISA, ICC/IF, IHC-P, PepArr, WB in human, mouse, rat samples.
Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) has been cited over 57 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality manufacturing and validation processes ensure Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) has 12 independent reviews from customers.
Anti-Histone H3 (tri methyl K27) antibody [EPR18607] - ChIP Grade (ab192985) specifically detects Histone H3 Tri Methyl-K27 (UniProt ID: P68431; Molecular weight: 15kDa) and is sold in a convenient trial size to enable initial testing (10 uL) and larger sizes for subsequent scaling up experiments (100 uL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone EPR18607 -
ab222481
Antibody clone EPR18607 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 75 (
ab27162
ab27163
ab32133
H3K27me3 is a crucial epigenetic modification that involves the tri-methylation of lysine 27 on histone H3, leading to gene repression. This modification is significant in various cancers, where it helps regulate gene expression and maintain chromatin structure. Utilizing our anti tri methyl K27 antibody can enhance the detection and study of H3K27me3, providing insights into its role in cancer development and potential therapeutic targets This antibody is crucial in chromatin remodeling research, particularly in understanding the role of H3K27me3 in transcription regulation. It is widely used in studies of Polycomb repressive complexes and histone methylation.Histone H3 lysine 27 methylation (H3K27) is a key marker associated with heterochromatin formation and widely used as a marker for transcriptional repression. This antibody is also validated for ChIP-seq, which is a key application to map protein-DNA interactions on a genome-wide scale using NGS.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle