Abcam, ab193470, Anti-UCP3 + UCP1 antibody [EPR19006]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal UCP1 antibody. Suitable for IP, WB and reacts with Mouse, Rat, Human, Recombinant full length protein - Mouse samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19006,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UCP3 also known as Uncoupling protein 3 is a mitochondrial protein that plays a role in the process of thermogenesis by dissipating the proton gradient. It is a member of the mitochondrial anion carrier proteins (MACP) and has a molecular mass of approximately 33 kDa. UCP3 is mostly expressed in skeletal muscle and to a lesser extent in brown adipose tissue. Its homolog UCP1 sometimes referred to as thermogenin has a similar function in brown adipose tissue where it participates prominently in heat production.
Biological function summary
Uncoupling proteins like UCP3 facilitate the regulation of energy balance and metabolism. They act by uncoupling ATP synthesis from the electrochemical gradient therefore reducing reactive oxygen species production. UCP3 is not part of a protein complex but interacts closely with the mitochondrial environment. UCP1 on the other hand is active in non-shivering thermogenesis within brown fat cells enabling organisms to fend off hypothermia.
Pathways
These uncoupling proteins play roles in energy homeostasis and lipid metabolism. UCP3 participates significantly in the fatty acid oxidation pathway influencing how cells utilize fatty acids for energy. UCP1 is an important player in the mitochondrial oxidative phosphorylation pathway where it influences heat production and energy expenditure. They are both connected to the broader metabolic pathways essential for maintaining energy balance interacting with other mitochondrial carriers.
UCP3 and UCP1 are associated with conditions like obesity and type 2 diabetes. UCP3 helps protect against lipid-induced mitochondrial damage which can be a factor in insulin resistance. Meanwhile UCP1’s disruption could lead to decreased ability in non-shivering thermogenesis contributing to weight gain. Both proteins hold therapeutic promise as targets to modulate metabolic conditions by influencing the body's energy expenditure.